Alachua (/əˈlætʃueɪ/ ⓘ ə-LATCH-oo-ay) is the second-most populous city in Alachua County, Florida, and the third-largest in North Central Florida. According to the 2020 census, the city's population was 10,574, up from 9,059 at the 2010 census. It is part of the Gainesville, Florida Metropolitan Statistical Area. Alachua has one of the largest bio and life sciences sectors in Florida and is the site for the Santa Fe College Perry Center for Emerging Technologies. Evidence of habitation by pre-historic Paleo-Indians exists in several documented locations within the San Felasco Hammock Preserve State Park. In the historic era, the primary town for the Potano tribe that lived throughout North Central Florida also was within San Felasco. This town became the site of the first Spanish doctrina (mission with a resident priest) in the Florida interior in 1606, Mission San Francisco de Potano, and it was the last to be abandoned by the Spanish in the early 1700s due to raids instigated by the British. Nearby to the north along the Santa Fe River was another mission, Santa Fe de Toloca, which was part of the mission chain stretching from St. Augustine to Pensacola. More information...
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